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KMID : 1144820200260010042
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대한의생명과학회지
2020 Volume.26 No. 1 p.42 ~ p.46
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Replication Study of Association between Forkhead Box O3 (FOXO3) Polymorphisms and Tuberculosis in Korean Population
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Park Sang-Jung
Kim Sung-Soo
Jin Hyun-Seok
Cho Jang-Eun
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Abstract
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Tuberculosis (TB) remains a major health problem worldwide. TB depends not only on the characteristics of the Mycobacterium tuberculosis (MTB) but also on the genetic susceptibility of infected patients. Recent studies have suggested that FOXO3 play an important role in the human immune associated disorder, such as TB. It was previously reported that FOXO3 genetic variants associated with a risk of TB in Chinese population. In this study, we confirm whether the genetic polymorphism of the FOXO3 gene, which was previously in Chinese, is reproduced in Korean population. Of the 154 SNPs were extracted from the FOXO3 gene, reproducibility analysis of the four SNPs performed in the previous study showed that there was a statistically significant correlation in the three SNPs (rs4946935, rs1536057, rs3800228). This study suggests that polymorphism of the FOXO3 gene in Koreans may affect the onset of tuberculosis and could be used to treat and prevent tuberculosis.
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KEYWORD
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Tuberculosis, Mycobacterium tuberculosis, FOXO3, SNPs
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